MASTL


Summary: This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microtubule associated serine/threonine kinase likeMIM:608221Ensembl:ENSG00000120539HGNC:HGNC:19042PA13494378110p12.1

GO terms in MASTL


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000086G2/M transition of mitotic cell cycle
BPIMPGO:0000278mitotic cell cycle
BPISSGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007147female meiosis II
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0032515negative regulation of phosphoprotein phosphatase activity
BPIBAGO:0035556intracellular signal transduction
BPIEAGO:0051301cell division
BPIMPGO:0051726regulation of cell cycle
BPIEAGO:1904668positive regulation of ubiquitin protein ligase activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCIDAGO:0032154cleavage furrow
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFISSGO:0051721protein phosphatase 2A binding

Gene expression in normal tissue: MASTL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MASTL


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2465910MASTL Facilitates Mitotic Progression
reactomeR-HSA-2465910MASTL Facilitates Mitotic Progression
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD405PIK-755
iGMDRD512nutlin 34
iGMDRD1008SR-II-138A2
iGMDRD420Leucascandrolide A2
iGMDRD634SCHEMBL26080414
iGMDRD945ML2142
iGMDRD466Chaetocin3
iGMDRD152179324-69-71
iGMDRD193Fqi13
iGMDRD446LY 21832404
iGMDRD289Parthenolide3
iGMDRD105Triptolide1
iGMDRD121GMX17782
iGMDRD137Indisulam4
iGMDRD322FK 8662
iGMDRD64Parbendazole5
iGMDRD562Navitoclax2
iGMDRD367Ro 28-16752
iGMDRD188Piperlongumine2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MASTL

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