RIPK3


Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
receptor interacting serine/threonine kinase 3MIM:605817Ensembl:ENSG00000129465HGNC:HGNC:10021PA3439614q12

GO terms in RIPK3


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003713transcription coactivator activity
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004704NF-kappaB-inducing kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
MFIMPGO:0044877protein-containing complex binding
BPISSGO:0001914regulation of T cell mediated cytotoxicity
BPISSGO:0002819regulation of adaptive immune response
BPTASGO:0006464cellular protein modification process
BPTASGO:0007165signal transduction
BPIEAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0010922positive regulation of phosphatase activity
BPIMPGO:0032147activation of protein kinase activity
BPISSGO:0032649regulation of interferon-gamma production
BPISSGO:0033077T cell differentiation in thymus
BPIEAGO:0038061NIK/NF-kappaB signaling
BPISSGO:0043029T cell homeostasis
BPISSGO:0046006regulation of activated T cell proliferation
BPIDAGO:0046777protein autophosphorylation
BPISSGO:0048535lymph node development
BPISSGO:0048536spleen development
BPISSGO:0048538thymus development
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051260protein homooligomerization
BPIMPGO:0051291protein heterooligomerization
BPIEAGO:0051351positive regulation of ligase activity
BPIEAGO:0051353positive regulation of oxidoreductase activity
BPIDAGO:0060545positive regulation of necroptotic process
BPIMPGO:0060545positive regulation of necroptotic process
BPISSGO:0070235regulation of activation-induced cell death of T cells
BPIMPGO:0070266necroptotic process
BPTASGO:0070266necroptotic process
BPTASGO:0097190apoptotic signaling pathway
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
BPIMPGO:1990000amyloid fibril formation
BPIEAGO:2000379positive regulation of reactive oxygen species metabolic process
BPISSGO:2000452regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
BPIEAGO:2001244positive regulation of intrinsic apoptotic signaling pathway
CCIEAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane

Gene expression in normal tissue: RIPK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIPK3


DatabasePathway IDPathway Des.
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
netpathPathway_TNFalphaTNFalpha
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-2562578TRIF-mediated programmed cell death
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-3295583TRP channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-9013957TLR3-mediated TICAM1-dependent programmed cell death
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib5
iGMDRD512nutlin 33
iGMDRD772BRD47703
iGMDRD560MK-22062
iGMDRD427ABT7373
iGMDRD85Ursolic acid4
iGMDRD280CYTOCHALASIN B3
iGMDRD177Teniposide1
iGMDRD634SCHEMBL26080413
iGMDRD511CHEMBL3993793
iGMDRD103SN-383
iGMDRD480KU00606483
iGMDRD474Avrainvillamide3
iGMDRD782DC-45-A23
iGMDRD318PAC-16
iGMDRD77Itraconazole3
iGMDRD329Merck602
iGMDRD562Navitoclax4
iGMDRD300Tozasertib3
iGMDRD369TGX-1152

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPK3

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