TNFRSF4
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 4 | MIM:600315 | Ensembl:ENSG00000186827 | HGNC:HGNC:11918 | PA36611 | 1p36.33 |
GO terms in TNFRSF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | TAS | GO:0005031 | tumor necrosis factor-activated receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0006955 | immune response |
| BP | ISS | GO:0030890 | positive regulation of B cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0042098 | T cell proliferation |
| BP | ISS | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | ISS | GO:0051024 | positive regulation of immunoglobulin secretion |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
Gene expression in normal tissue: TNFRSF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD201 | SKI II | 5 |
| iGMDRD375 | GW-405833 | 9 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD579 | PF750 | 5 |
| iGMDRD79 | Gemcitabine | 9 |
| iGMDRD652 | UNC0638 | 6 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD150 | RITA | 2 |
| iGMDRD144 | NSC95397 | 10 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD269 | Purmorphamine | 5 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD887 | Compound 23 citrate | 6 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD474 | Avrainvillamide | 8 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD434 | BMS-536924 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF4
CLASSFICATION
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