TNFRSF4


Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TNF receptor superfamily member 4MIM:600315Ensembl:ENSG00000186827HGNC:HGNC:11918PA366111p36.33

GO terms in TNFRSF4


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFTASGO:0005031tumor necrosis factor-activated receptor activity
MFIPIGO:0005515protein binding
BPTASGO:0006955immune response
BPISSGO:0030890positive regulation of B cell proliferation
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPISSGO:0042098T cell proliferation
BPISSGO:0043433negative regulation of DNA-binding transcription factor activity
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0046718viral entry into host cell
BPISSGO:0051024positive regulation of immunoglobulin secretion
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCISSGO:0009986cell surface

Gene expression in normal tissue: TNFRSF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF4


DatabasePathway IDPathway Des.
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD201SKI II5
iGMDRD375GW-4058339
iGMDRD634SCHEMBL26080412
iGMDRD154NSC237665
iGMDRD579PF7505
iGMDRD79Gemcitabine9
iGMDRD652UNC06386
iGMDRD781Sirolimus6
iGMDRD150RITA2
iGMDRD144NSC9539710
iGMDRD577BIX012946
iGMDRD269Purmorphamine5
iGMDRD188Piperlongumine4
iGMDRD887Compound 23 citrate6
iGMDRD300Tozasertib6
iGMDRD60Quinoclamine1
iGMDRD8024-methylfasudil3
iGMDRD474Avrainvillamide8
iGMDRD885Compound 1103
iGMDRD267Oligomycin A2
iGMDRD221Tamoxifen5
iGMDRD434BMS-5369241

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF4

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