BMPR2


Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
bone morphogenetic protein receptor type 2MIM:600799Ensembl:ENSG00000204217HGNC:HGNC:1078PA253882q33.1-q33.2

GO terms in BMPR2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0001568blood vessel development
BPISSGO:0001707mesoderm formation
BPIEAGO:0001893maternal placenta development
BPIMPGO:0001935endothelial cell proliferation
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPIBAGO:0001944vasculature development
BPISSGO:0001946lymphangiogenesis
BPISSGO:0001974blood vessel remodeling
BPIMPGO:0002063chondrocyte development
BPIMPGO:0003085negative regulation of systemic arterial blood pressure
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003181atrioventricular valve morphogenesis
BPISSGO:0003183mitral valve morphogenesis
BPISSGO:0003186tricuspid valve morphogenesis
BPISSGO:0003197endocardial cushion development
BPISSGO:0003252negative regulation of cell proliferation involved in heart valve morphogenesis
BPIMPGO:0006366transcription by RNA polymerase II
BPIEAGO:0006468protein phosphorylation
BPIDAGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIBAGO:0007389pattern specification process
BPIEAGO:0007420brain development
BPIEPGO:0009267cellular response to starvation
BPISSGO:0009952anterior/posterior pattern specification
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0010634positive regulation of epithelial cell migration
BPIMPGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIMPGO:0014916regulation of lung blood pressure
BPISSGO:0014916regulation of lung blood pressure
BPISSGO:0030166proteoglycan biosynthetic process
BPIDAGO:0030308negative regulation of cell growth
BPIMPGO:0030501positive regulation of bone mineralization
BPIDAGO:0030509BMP signaling pathway
BPIMPGO:0030509BMP signaling pathway
BPISSGO:0030509BMP signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIMPGO:0030513positive regulation of BMP signaling pathway
BPIEAGO:0032924activin receptor signaling pathway
BPIMPGO:0042127regulation of cell proliferation
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPISSGO:0045778positive regulation of ossification
BPISSGO:0045906negative regulation of vasoconstriction
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048286lung alveolus development
BPISSGO:0048738cardiac muscle tissue development
BPIEAGO:0048842positive regulation of axon extension involved in axon guidance
BPIEAGO:0060173limb development
BPISSGO:0060350endochondral bone morphogenesis
BPISSGO:0060412ventricular septum morphogenesis
BPISSGO:0060413atrial septum morphogenesis
BPISSGO:0060836lymphatic endothelial cell differentiation
BPISSGO:0060840artery development
BPISSGO:0060841venous blood vessel development
BPISSGO:0061036positive regulation of cartilage development
BPISSGO:0061298retina vasculature development in camera-type eye
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPIMPGO:0071773cellular response to BMP stimulus
BPIMPGO:0072577endothelial cell apoptotic process
BPIMPGO:1902731negative regulation of chondrocyte proliferation
BPISSGO:1905314semi-lunar valve development
BPIMPGO:2000279negative regulation of DNA biosynthetic process
CCHDAGO:0005615extracellular space
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIMPGO:0005901caveola
CCIDAGO:0005913cell-cell adherens junction
CCIEAGO:0009925basal plasma membrane
CCIEAGO:0009986cell surface
CCIEAGO:0014069postsynaptic density
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0030425dendrite
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCTASGO:0044214spanning component of plasma membrane
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005026transforming growth factor beta receptor activity, type II
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016362activin receptor activity, type II
MFIBAGO:0019838growth factor binding
MFIEAGO:0019838growth factor binding
MFIPIGO:0036122BMP binding
MFIBAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0098821BMP receptor activity
MFISSGO:0098821BMP receptor activity

Gene expression in normal tissue: BMPR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BMPR2


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidalk1pathwayALK1 signaling events
pidalk2pathwayALK2 signaling events
pidbmppathwayBMP receptor signaling
humancycPWY66-11BMP Signalling Pathway
wikipathwaysWP1425Bone Morphogenic Protein (BMP) Signalling and Regulation
wikipathwaysWP1591Heart Development
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3931ESC Pluripotency Pathways
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members
biocartaalkpathwayalk in cardiac myocytes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD466Chaetocin2
iGMDRD679Bistramide A3
iGMDRD375GW-4058332
iGMDRD945ML2144
iGMDRD797ISOX DUAL2
iGMDRD201SKI II2
iGMDRD57Chloropentafluorobenzene2
iGMDRD314Tanespimycin1
iGMDRD61Kinetin riboside1
iGMDRD494Neopeltolide2
iGMDRD276AS 6052401
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD79Gemcitabine3
iGMDRD126Tipifarnib2
iGMDRD772BRD47702
iGMDRD640CAY106183
iGMDRD353PD03259011
iGMDRD356PNU-746543
iGMDRD322FK 8665
iGMDRD188Piperlongumine4
iGMDRD100Zebularine2
iGMDRD887Compound 23 citrate2
iGMDRD662JQ-13
iGMDRD269Purmorphamine2
iGMDRD398Sepantronium2
iGMDRD289Parthenolide2
iGMDRD171Pemetrexed3
iGMDRD187BRD98764
iGMDRD298L-6854582
iGMDRD121GMX17784

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMPR2

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