CCNT1
Summary: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin T1 | MIM:143055 | Ensembl:ENSG00000129315 | HGNC:HGNC:1599 | PA26163 | 12q13.11-q13.12 |
GO terms in CCNT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IPI | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | NAS | GO:0043923 | positive regulation by host of viral transcription |
| BP | IBA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0050434 | positive regulation of viral transcription |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:1900364 | negative regulation of mRNA polyadenylation |
| BP | IBA | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0070063 | RNA polymerase binding |
| MF | IDA | GO:0097322 | 7SK snRNA binding |
Gene expression in normal tissue: CCNT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation |
| reactome | R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167287 | HIV elongation arrest and recovery |
| reactome | R-HSA-167290 | Pausing and recovery of HIV elongation |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-176034 | Interactions of Tat with host cellular proteins |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD298 | L-685458 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD210 | AC55649 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNT1
CLASSFICATION
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