GRK4


Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor kinase 4MIM:137026Ensembl:ENSG00000125388HGNC:HGNC:4543PA289414p16.3

GO terms in GRK4


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002031G-protein coupled receptor internalization
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0007165signal transduction
BPTASGO:0008277regulation of G-protein coupled receptor protein signaling pathway
BPTASGO:0022400regulation of rhodopsin mediated signaling pathway
BPIDAGO:0031623receptor internalization
CCIEAGO:0005829cytosol
CCIEAGO:0005938cell cortex
CCIEAGO:0030425dendrite
CCIEAGO:0043025neuronal cell body
CCTASGO:0097381photoreceptor disc membrane
MFIEAGO:0004703G-protein coupled receptor kinase activity
MFIEAGO:0005524ATP binding
MFTASGO:0050254rhodopsin kinase activity

Gene expression in normal tissue: GRK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK4


DatabasePathway IDPathway Des.
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
biocartaagpcrpathwayattenuation of gpcr signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832402
iGMDRD85Ursolic acid2
iGMDRD57Chloropentafluorobenzene3
iGMDRD314Tanespimycin5
iGMDRD61Kinetin riboside2
iGMDRD193Fqi14
iGMDRD297Austocystin D2
iGMDRD466Chaetocin2
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD409Saracatinib1
iGMDRD1008SR-II-138A1
iGMDRD420Leucascandrolide A2
iGMDRD424Tamatinib6
iGMDRD79Gemcitabine4
iGMDRD652UNC06383
iGMDRD286Nsc 6328394
iGMDRD872BRD71372
iGMDRD562Navitoclax4
iGMDRD60Quinoclamine2
iGMDRD64Parbendazole4
iGMDRD246NPC262
iGMDRD451Serdemetan2
iGMDRD524ISX-93
iGMDRD158NSC1415406
iGMDRD255SB2250024
iGMDRD105Triptolide1
iGMDRD782DC-45-A22
iGMDRD226ML0062
iGMDRD885Compound 1103
iGMDRD870BRD636101

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK4

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