IRAK2
Summary: IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor associated kinase 2 | MIM:603304 | Ensembl:ENSG00000134070 | HGNC:HGNC:6113 | PA29913 | 3p25.3 |
GO terms in IRAK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IBA | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
Gene expression in normal tissue: IRAK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRAK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il1rpathway | signal transduction through il1r |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937042 | IRAK2 mediated activation of TAK1 complex |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| netpath | Pathway_IL1 | IL1 |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD690 | PRIMA-1MET | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRAK2
CLASSFICATION
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