TBK1


Summary: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TANK binding kinase 1MIM:604834Ensembl:ENSG00000183735HGNC:HGNC:11584PA3634812q14.2

GO terms in TBK1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0010008endosome membrane
CCIDAGO:0016235aggresome
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006954inflammatory response
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0009615response to virus
BPIEAGO:0010629negative regulation of gene expression
BPIEAGO:0016032viral process
BPIDAGO:0016239positive regulation of macroautophagy
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0032479regulation of type I interferon production
BPTASGO:0032480negative regulation of type I interferon production
BPTASGO:0032481positive regulation of type I interferon production
BPTASGO:0032606type I interferon production
BPIDAGO:0032727positive regulation of interferon-alpha production
BPIDAGO:0032728positive regulation of interferon-beta production
BPNASGO:0033138positive regulation of peptidyl-serine phosphorylation
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0044565dendritic cell proliferation
BPTASGO:0045087innate immune response
BPIEAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0050830defense response to Gram-positive bacterium
BPIEAGO:0051607defense response to virus
BPTASGO:0071345cellular response to cytokine stimulus
BPNASGO:1901214regulation of neuron death
BPIEAGO:1904417positive regulation of xenophagy
MFIEAGO:0003676nucleic acid binding
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0051219phosphoprotein binding

Gene expression in normal tissue: TBK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TBK1


DatabasePathway IDPathway Des.
netpathPathway_TNFalphaTNFalpha
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP3851TLR4 Signaling and Tolerance
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP75Toll-like Receptor Signaling Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-1606341IRF3 mediated activation of type 1 IFN
reactomeR-HSA-1606341IRF3 mediated activation of type 1 IFN
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1834941STING mediated induction of host immune responses
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-3134975Regulation of innate immune responses to cytosolic DNA
reactomeR-HSA-3249367STAT6-mediated induction of chemokines
reactomeR-HSA-3270619IRF3-mediated induction of type I IFN
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-9008059Interleukin-37 signaling
reactomeR-HSA-9013973TICAM1-dependent activation of IRF3/IRF7
reactomeR-HSA-918233TRAF3-dependent IRF activation pathway
reactomeR-HSA-933541TRAF6 mediated IRF7 activation
reactomeR-HSA-936440Negative regulators of DDX58/IFIH1 signaling
reactomeR-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD330BRD41322
iGMDRD512nutlin 35
iGMDRD546BMS-7548072
iGMDRD781Sirolimus4
iGMDRD494Neopeltolide1
iGMDRD523Cyanoquinoline, 114
iGMDRD799AZ9091
iGMDRD123Isoevodiamine1
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD945ML2141
iGMDRD154NSC237661
iGMDRD121GMX17782
iGMDRD474Avrainvillamide1
iGMDRD434BMS-5369241
iGMDRD30917AAG2
iGMDRD267Oligomycin A7
iGMDRD318PAC-11
iGMDRD399Selumetinib1
iGMDRD562Navitoclax5
iGMDRD780PP-303
iGMDRD60Quinoclamine4
iGMDRD886Compound 1541A1
iGMDRD268Cerulenin1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TBK1

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