ABL2


Summary: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ABL proto-oncogene 2, non-receptor tyrosine kinaseMIM:164690Ensembl:ENSG00000143322HGNC:HGNC:77PA244141q25.2

GO terms in ABL2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005829cytosol
CCTASGO:0015629actin cytoskeleton
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
BPTASGO:0006464cellular protein modification process
BPIEAGO:0007155cell adhesion
BPTASGO:0007165signal transduction
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIMPGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0010506regulation of autophagy
BPIMPGO:0010863positive regulation of phospholipase C activity
BPIMPGO:0010976positive regulation of neuron projection development
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0030100regulation of endocytosis
BPIBAGO:0030154cell differentiation
BPTASGO:0030155regulation of cell adhesion
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0042981regulation of apoptotic process
BPIBAGO:0045087innate immune response
BPIDAGO:0051353positive regulation of oxidoreductase activity
BPIMPGO:0071300cellular response to retinoic acid
BPTASGO:2000145regulation of cell motility
BPTASGO:2000249regulation of actin cytoskeleton reorganization
MFIDAGO:0000287magnesium ion binding
MFIPIGO:0001784phosphotyrosine residue binding
MFTASGO:0003785actin monomer binding
MFTASGO:0004672protein kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFTASGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0030145manganese ion binding
MFTASGO:0051015actin filament binding

Gene expression in normal tissue: ABL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABL2


DatabasePathway IDPathway Des.
biocartaactinypathwayy branching of actin filaments
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
reactomeR-HSA-428890Role of ABL in ROBO-SLIT signaling
wikipathwaysWP4223Ras Signaling
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250022
iGMDRD434BMS-5369242
iGMDRD6AM-5806
iGMDRD52Rotenone3
iGMDRD887Compound 23 citrate2
iGMDRD286Nsc 6328392
iGMDRD67PENFLURIDOL3
iGMDRD562Navitoclax2
iGMDRD329Merck604
iGMDRD640CAY106181
iGMDRD886Compound 1541A3
iGMDRD82Quiflapon3
iGMDRD356PNU-746543
iGMDRD126Tipifarnib6
iGMDRD84Lovastatin acid3
iGMDRD579PF7503
iGMDRD599Salermide3
iGMDRD424Tamatinib2
iGMDRD79Gemcitabine5
iGMDRD61Kinetin riboside3
iGMDRD152179324-69-73
iGMDRD394BX-7953
iGMDRD901ELCPK3
iGMDRD297Austocystin D6
iGMDRD375GW-4058333

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABL2

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