PDK4
Summary: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pyruvate dehydrogenase kinase 4 | MIM:602527 | Ensembl:ENSG00000004799 | HGNC:HGNC:8812 | PA33157 | 7q21.3 |
GO terms in PDK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006885 | regulation of pH |
| BP | IMP | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0009267 | cellular response to starvation |
| BP | IMP | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | TAS | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | ISS | GO:0010565 | regulation of cellular ketone metabolic process |
| BP | IMP | GO:0010906 | regulation of glucose metabolic process |
| BP | IMP | GO:0042304 | regulation of fatty acid biosynthetic process |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0042594 | response to starvation |
| BP | IEA | GO:0045124 | regulation of bone resorption |
| BP | ISS | GO:0046320 | regulation of fatty acid oxidation |
| BP | IMP | GO:0071398 | cellular response to fatty acid |
| BP | IMP | GO:0072593 | reactive oxygen species metabolic process |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| CC | TAS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | ISS | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: PDK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2881 | Estrogen Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3925 | Amino Acid metabolism |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD116 | CD437 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD797 | ISOX DUAL | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD329 | Merck60 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDK4
CLASSFICATION
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