PLK4


Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
polo like kinase 4MIM:605031Ensembl:ENSG00000142731HGNC:HGNC:11397PA362054q28.1

GO terms in PLK4


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004674protein serine/threonine kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0007099centriole replication
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIDAGO:0046601positive regulation of centriole replication
BPIMPGO:0046601positive regulation of centriole replication
BPISSGO:0060707trophoblast giant cell differentiation
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPISSGO:0098535de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
CCIEAGO:0001741XY body
CCISSGO:0005730nucleolus
CCIDAGO:0005813centrosome
CCIDAGO:0005814centriole
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0032154cleavage furrow
CCISSGO:0098536deuterosome

Gene expression in normal tissue: PLK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLK4


DatabasePathway IDPathway Des.
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8854518AURKA Activation by TPX2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib3
iGMDRD887Compound 23 citrate3
iGMDRD506Fedratinib3
iGMDRD366PI-1031
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide1
iGMDRD289Parthenolide4
iGMDRD52Rotenone3
iGMDRD255SB2250021
iGMDRD123Isoevodiamine3
iGMDRD435BI-25363
iGMDRD945ML2143
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD219Bax channel blocker3
iGMDRD560MK-22062
iGMDRD670ML 2102
iGMDRD424Tamatinib2
iGMDRD494Neopeltolide3
iGMDRD79Gemcitabine1
iGMDRD151CHM-13
iGMDRD433Lexibulin1
iGMDRD512nutlin 33
iGMDRD420Leucascandrolide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLK4

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