TIMP3
Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TIMP metallopeptidase inhibitor 3 | MIM:188826 | Ensembl:ENSG00000100234 | HGNC:HGNC:11822 | PA36528 | 22q12.3 |
GO terms in TIMP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005604 | basement membrane |
| CC | IBA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | TAS | GO:0031089 | platelet dense granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IEA | GO:0007601 | visual perception |
| BP | IBA | GO:0009725 | response to hormone |
| BP | IBA | GO:0010033 | response to organic substance |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| BP | IMP | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| BP | IMP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071310 | cellular response to organic substance |
| BP | IMP | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway |
| BP | ISS | GO:1904684 | negative regulation of metalloendopeptidase activity |
| MF | IBA | GO:0002020 | protease binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008191 | metalloendopeptidase inhibitor activity |
| MF | TAS | GO:0008191 | metalloendopeptidase inhibitor activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: TIMP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIMP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP474 | Endochondral Ossification |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| biocarta | p53pathway | p53 signaling pathway |
| biocarta | reckpathway | inhibition of matrix metalloproteinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIMP3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.