YES1


Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
YES proto-oncogene 1, Src family tyrosine kinaseMIM:164880Ensembl:ENSG00000176105HGNC:HGNC:12841PA3743218p11.32

GO terms in YES1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005884actin filament
CCIDAGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCHDAGO:0070062extracellular exosome
BPTASGO:0006464cellular protein modification process
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIEAGO:0010827regulation of glucose transmembrane transport
BPIBAGO:0030154cell differentiation
BPTASGO:0031295T cell costimulation
BPIEAGO:0036120cellular response to platelet-derived growth factor stimulus
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIBAGO:0042127regulation of cell proliferation
BPTASGO:0043114regulation of vascular permeability
BPIBAGO:0045087innate immune response
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0048013ephrin receptor signaling pathway
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPTASGO:0050900leukocyte migration
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0071560cellular response to transforming growth factor beta stimulus
MFIPIGO:0001784phosphotyrosine residue binding
MFEXPGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFTASGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIEAGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0044325ion channel binding

Gene expression in normal tissue: YES1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YES1


DatabasePathway IDPathway Des.
pidalphasynuclein_pathwayAlpha-synuclein signaling
pidcdc42_pathwayCDC42 signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
pidepha_fwdpathwayEPHA forward signaling
pidephrinbrevpathwayEphrin B reverse signaling
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidglypican_1pathwayGlypican 1 network
pidnetrin_pathwayNetrin-mediated signaling events
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidptp1bpathwaySignaling events mediated by PTP1B
pidtxa2pathwayThromboxane A2 receptor signaling
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04520Adherens junction - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_KitReceptorKitReceptor
netpathPathway_WntWnt
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1433559Regulation of KIT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029481FCGR activation
reactomeR-HSA-210990PECAM1 interactions
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389513CTLA4 inhibitory signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-912631Regulation of signaling by CBL

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD144NSC953975
iGMDRD150RITA2
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside6
iGMDRD57Chloropentafluorobenzene2
iGMDRD297Austocystin D3
iGMDRD945ML2144
iGMDRD138PX 123
iGMDRD103SN-383
iGMDRD289Parthenolide2
iGMDRD318PAC-11
iGMDRD885Compound 1103
iGMDRD872BRD71373
iGMDRD871BRD63686
iGMDRD414MST-3123
iGMDRD577BIX012942
iGMDRD506Fedratinib3
iGMDRD263AACOCF33
iGMDRD886Compound 1541A2
iGMDRD42Vorinostat3
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YES1

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