ACSL6


Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
acyl-CoA synthetase long chain family member 6MIM:604443Ensembl:ENSG00000164398HGNC:HGNC:16496PA279705q31.1

GO terms in ACSL6


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0004467long-chain fatty acid-CoA ligase activity
MFTASGO:0004467long-chain fatty acid-CoA ligase activity
MFIEAGO:0005524ATP binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0102391decanoate-CoA ligase activity
CCIEAGO:0005741mitochondrial outer membrane
CCIEAGO:0005778peroxisomal membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCNASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0001676long-chain fatty acid metabolic process
BPNASGO:0006637acyl-CoA metabolic process
BPTASGO:0035338long-chain fatty-acyl-CoA biosynthetic process

Gene expression in normal tissue: ACSL6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACSL6


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-75105Fatty acyl-CoA biosynthesis
reactomeR-HSA-75876Synthesis of very long-chain fatty acyl-CoAs
reactomeR-HSA-8978868Fatty acid metabolism
kegghsa00061Fatty acid biosynthesis - Homo sapiens (human)
kegghsa00071Fatty acid degradation - Homo sapiens (human)
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04146Peroxisome - Homo sapiens (human)
kegghsa04216Ferroptosis - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
humancycFAO-PWYfatty acid β-oxidation
humancycPWY-5143fatty acid activation
humancycPWY-6000γ-linolenate biosynthesis
humancycPWY-7049icosapentaenoate biosynthesis II (metazoa)
humancycPWY66-391fatty acid β-oxidation (peroxisome)
wikipathwaysWP143Fatty Acid Beta Oxidation
wikipathwaysWP357Fatty Acid Biosynthesis
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP4010Liver steatosis AOP

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD546BMS-7548072
iGMDRD779PRL-3 Inhibitor I1
iGMDRD494Neopeltolide4
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib1
iGMDRD84Lovastatin acid1
iGMDRD554CHEMBL14341372
iGMDRD210AC556493
iGMDRD420Leucascandrolide A3
iGMDRD634SCHEMBL26080413
iGMDRD201SKI II2
iGMDRD351GW843682X3
iGMDRD237ABT-7512
iGMDRD105Triptolide3
iGMDRD885Compound 1101
iGMDRD30917AAG2
iGMDRD52Rotenone2
iGMDRD103SN-383
iGMDRD137Indisulam2
iGMDRD158NSC1415401
iGMDRD246NPC263
iGMDRD82Quiflapon1
iGMDRD23Gossypol1
iGMDRD100Zebularine1
iGMDRD577BIX012946
iGMDRD780PP-304

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACSL6

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