BRSK1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BR serine/threonine kinase 1 | MIM:609235 | Ensembl:ENSG00000160469 | HGNC:HGNC:18994 | PA134888976 | 19q13.42 |
GO terms in BRSK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IC | GO:0005524 | ATP binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0043015 | gamma-tubulin binding |
| MF | IBA | GO:0050321 | tau-protein kinase activity |
| MF | IDA | GO:0050321 | tau-protein kinase activity |
| MF | ISS | GO:0050321 | tau-protein kinase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | ISS | GO:0005813 | centrosome |
| CC | ISS | GO:0008021 | synaptic vesicle |
| CC | TAS | GO:0008021 | synaptic vesicle |
| CC | IDA | GO:0030054 | cell junction |
| CC | TAS | GO:0048786 | presynaptic active zone |
| CC | ISS | GO:0150034 | distal axon |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | ISS | GO:0007269 | neurotransmitter secretion |
| BP | IBA | GO:0007409 | axonogenesis |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | ISS | GO:0008306 | associative learning |
| BP | IDA | GO:0009411 | response to UV |
| BP | IDA | GO:0010212 | response to ionizing radiation |
| BP | ISS | GO:0010975 | regulation of neuron projection development |
| BP | IBA | GO:0030010 | establishment of cell polarity |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | ISS | GO:0050770 | regulation of axonogenesis |
| BP | ISS | GO:0051298 | centrosome duplication |
| BP | ISS | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity |
| BP | ISS | GO:0099504 | synaptic vesicle cycle |
| BP | TAS | GO:2000807 | regulation of synaptic vesicle clustering |
Gene expression in normal tissue: BRSK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD359 | OSW-1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRSK1
CLASSFICATION
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