DNAAF3
Summary: The protein encoded by this gene is required for the assembly of axonemal inner and outer dynein arms and plays a role in assembling dynein complexes for transport into cilia. Defects in this gene are a cause of primary ciliary dyskinesia type 2 (CILD2). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dynein axonemal assembly factor 3 | MIM:614566 | Ensembl:ENSG00000167646 | HGNC:HGNC:30492 | PA147358371 | 19q13.42 |
GO terms in DNAAF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IMP | GO:0044458 | motile cilium assembly |
| BP | IMP | GO:0070286 | axonemal dynein complex assembly |
Gene expression in normal tissue: DNAAF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNAAF3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 9 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD171 | Pemetrexed | 5 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD150 | RITA | 1 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD607 | Ubistatin B | 5 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNAAF3
CLASSFICATION
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