NFATC1
Summary: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor of activated T cells 1 | MIM:600489 | Ensembl:ENSG00000131196 | HGNC:HGNC:7775 | PA31582 | 18q23 |
GO terms in NFATC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | ISS | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IEA | GO:0001225 | RNA polymerase II transcription coactivator binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | ISS | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005528 | FK506 binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | ISS | GO:0048273 | mitogen-activated protein kinase p38 binding |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IBA | GO:0044798 | nuclear transcription factor complex |
| BP | IBA | GO:0001816 | cytokine production |
| BP | IBA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | ISS | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IBA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IDA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation |
Gene expression in normal tissue: NFATC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFATC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 5 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD414 | MST-312 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFATC1
CLASSFICATION
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