NGF


Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nerve growth factorMIM:162030Ensembl:ENSG00000134259HGNC:HGNC:7808PA1623974751p13.2

GO terms in NGF


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCTASGO:0005768endosome
CCTASGO:0005796Golgi lumen
CCIBAGO:0008021synaptic vesicle
CCIBAGO:0030424axon
CCIBAGO:0030425dendrite
CCIBAGO:0031410cytoplasmic vesicle
BPTASGO:0000186activation of MAPKK activity
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007267cell-cell signaling
BPIBAGO:0007422peripheral nervous system development
BPIBAGO:0007613memory
BPTASGO:0008285negative regulation of cell proliferation
BPIDAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0010469regulation of signaling receptor activity
BPIMPGO:0010628positive regulation of gene expression
BPISSGO:0010628positive regulation of gene expression
BPIBAGO:0021675nerve development
BPTASGO:0032455nerve growth factor processing
BPIBAGO:0038180nerve growth factor signaling pathway
BPIBAGO:0040011locomotion
BPTASGO:0043065positive regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPISSGO:0043388positive regulation of DNA binding
BPIBAGO:0043524negative regulation of neuron apoptotic process
BPIBAGO:0045664regulation of neuron differentiation
BPTASGO:0045666positive regulation of neuron differentiation
BPISSGO:0046579positive regulation of Ras protein signal transduction
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPIBAGO:0048672positive regulation of collateral sprouting
BPIBAGO:0048812neuron projection morphogenesis
BPIDAGO:0048812neuron projection morphogenesis
BPTASGO:0050772positive regulation of axonogenesis
BPIBAGO:0050804modulation of chemical synaptic transmission
MFIBAGO:0005163nerve growth factor receptor binding
MFIPIGO:0005163nerve growth factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008191metalloendopeptidase inhibitor activity

Gene expression in normal tissue: NGF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NGF


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167021PLC-gamma1 signalling
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167060NGF processing
reactomeR-HSA-167060NGF processing
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170984ARMS-mediated activation
reactomeR-HSA-170984ARMS-mediated activation
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-187015Activation of TRKA receptors
reactomeR-HSA-187015Activation of TRKA receptors
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187042TRKA activation by NGF
reactomeR-HSA-187042TRKA activation by NGF
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187706Signalling to p38 via RIT and RIN
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193670p75NTR negatively regulates cell cycle via SC1
reactomeR-HSA-193681Ceramide signalling
reactomeR-HSA-193697p75NTR regulates axonogenesis
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198745Signalling to STAT3
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-205017NFG and proNGF binds to p75NTR
reactomeR-HSA-205025NADE modulates death signalling
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-209563Axonal growth stimulation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9036866Expression and Processing of Neurotrophins
reactomeR-HSA-9036866Expression and Processing of Neurotrophins
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartangfpathwaynerve growth factor pathway (ngf)
biocartatrkapathwaytrka receptor signaling pathway
netpathPathway_BDNFBDNF
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3998Prader-Willi and Angelman Syndrome
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD524ISX-92
iGMDRD42Vorinostat4
iGMDRD577BIX012945
iGMDRD872BRD71372
iGMDRD286Nsc 6328394
iGMDRD414MST-3122
iGMDRD367Ro 28-16752
iGMDRD267Oligomycin A2
iGMDRD226ML0062
iGMDRD441TW 372
iGMDRD289Parthenolide1
iGMDRD255SB2250021
iGMDRD251ML1624
iGMDRD202Curcumin3
iGMDRD474Avrainvillamide1
iGMDRD945ML2145
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside1
iGMDRD2PK-111951
iGMDRD341Triacsin c1
iGMDRD144NSC953972
iGMDRD427ABT7374
iGMDRD150RITA2
iGMDRD554CHEMBL14341372
iGMDRD330BRD41323

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NGF

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