NTRK1


Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neurotrophic receptor tyrosine kinase 1MIM:191315Ensembl:ENSG00000198400HGNC:HGNC:8031PA318171q23.1

GO terms in NTRK1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005768endosome
CCISSGO:0005769early endosome
CCISSGO:0005770late endosome
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIEAGO:0009986cell surface
CCIBAGO:0030424axon
CCIEAGO:0030424axon
CCIEAGO:0030425dendrite
CCIEAGO:0031901early endosome membrane
CCIEAGO:0031902late endosome membrane
CCISSGO:0032991protein-containing complex
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
BPTASGO:0000186activation of MAPKK activity
BPTASGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007411axon guidance
BPIEAGO:0007568aging
BPIEAGO:0007611learning or memory
BPIEAGO:0007623circadian rhythm
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0009314response to radiation
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0010623programmed cell death involved in cell development
BPIDAGO:0010976positive regulation of neuron projection development
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021553olfactory nerve development
BPIBAGO:0030154cell differentiation
BPIEAGO:0030183B cell differentiation
BPIEAGO:0031667response to nutrient levels
BPIBAGO:0033674positive regulation of kinase activity
BPIMPGO:0038083peptidyl-tyrosine autophosphorylation
BPIMPGO:0038180nerve growth factor signaling pathway
BPIEAGO:0042490mechanoreceptor differentiation
BPIBAGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPISSGO:0043068positive regulation of programmed cell death
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0043524negative regulation of neuron apoptotic process
BPIDAGO:0043547positive regulation of GTPase activity
BPIDAGO:0046579positive regulation of Ras protein signal transduction
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0048011neurotrophin TRK receptor signaling pathway
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPIEAGO:0048013ephrin receptor signaling pathway
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPISSGO:0048485sympathetic nervous system development
BPIEAGO:0048678response to axon injury
BPIEAGO:0050965detection of temperature stimulus involved in sensory perception of pain
BPIEAGO:0050966detection of mechanical stimulus involved in sensory perception of pain
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051599response to hydrostatic pressure
BPIEAGO:0051602response to electrical stimulus
BPIEAGO:0051965positive regulation of synapse assembly
BPIEAGO:0051968positive regulation of synaptic transmission, glutamatergic
BPIEAGO:0060009Sertoli cell development
BPISSGO:0060385axonogenesis involved in innervation
BPIEAGO:0061368behavioral response to formalin induced pain
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071316cellular response to nicotine
BPIDAGO:1904646cellular response to amyloid-beta
BPIBAGO:1990090cellular response to nerve growth factor stimulus
BPIMPGO:1990090cellular response to nerve growth factor stimulus
BPISSGO:1990090cellular response to nerve growth factor stimulus
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIDAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIMPGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIEAGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005030neurotrophin receptor activity
MFIEAGO:0005166neurotrophin p75 receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0010465nerve growth factor receptor activity
MFIMPGO:0010465nerve growth factor receptor activity
MFIEAGO:0019900kinase binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIDAGO:0042803protein homodimerization activity
MFIBAGO:0043121neurotrophin binding
MFTASGO:0043121neurotrophin binding
MFIDAGO:0048406nerve growth factor binding

Gene expression in normal tissue: NTRK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTRK1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167021PLC-gamma1 signalling
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170984ARMS-mediated activation
reactomeR-HSA-170984ARMS-mediated activation
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-177504Retrograde neurotrophin signalling
reactomeR-HSA-187015Activation of TRKA receptors
reactomeR-HSA-187015Activation of TRKA receptors
reactomeR-HSA-187024NGF-independant TRKA activation
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187042TRKA activation by NGF
reactomeR-HSA-187042TRKA activation by NGF
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187706Signalling to p38 via RIT and RIN
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198745Signalling to STAT3
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartatrkapathwaytrka receptor signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
pidp73pathwayp73 transcription factor network
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD123Isoevodiamine6
iGMDRD280CYTOCHALASIN B3
iGMDRD698Neratinib3
iGMDRD193Fqi11
iGMDRD219Bax channel blocker3
iGMDRD446LY 21832404
iGMDRD781Sirolimus3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD889Compound 7d-cis2
iGMDRD420Leucascandrolide A3
iGMDRD126Tipifarnib2
iGMDRD433Lexibulin3
iGMDRD151CHM-11
iGMDRD356PNU-746542
iGMDRD64Parbendazole3
iGMDRD577BIX012943
iGMDRD506Fedratinib3
iGMDRD562Navitoclax2
iGMDRD398Sepantronium2
iGMDRD188Piperlongumine2
iGMDRD100Zebularine7
iGMDRD74Idarubicin2
iGMDRD434BMS-5369244
iGMDRD575Entrectinib2
iGMDRD8024-methylfasudil2
iGMDRD970Pan-TRK inhibitor2
iGMDRD137Indisulam3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTRK1

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