PIK3C2A


Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaMIM:603601Ensembl:ENSG00000011405HGNC:HGNC:8971PA3330411p15.1

GO terms in PIK3C2A


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPTASGO:0006887exocytosis
BPIMPGO:0006897endocytosis
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0008286insulin receptor signaling pathway
BPIBAGO:0014065phosphatidylinositol 3-kinase signaling
BPTASGO:0014829vascular smooth muscle contraction
BPIBAGO:0016477cell migration
BPIBAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048008platelet-derived growth factor receptor signaling pathway
BPIBAGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0048268clathrin coat assembly
BPTASGO:0061024membrane organization
BPIMPGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCHDAGO:0016020membrane
CCIBAGO:0016020membrane
CCIEAGO:0030136clathrin-coated vesicle
CCIDAGO:0031982vesicle
CCHDAGO:0070062extracellular exosome
MFIEAGO:0005524ATP binding
MFIBAGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0035004phosphatidylinositol 3-kinase activity
MFIBAGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFTASGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFIEAGO:0035091phosphatidylinositol binding
MFIBAGO:0052742phosphatidylinositol kinase activity

Gene expression in normal tissue: PIK3C2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3C2A


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-1660514Synthesis of PIPs at the Golgi membrane
reactomeR-HSA-1660516Synthesis of PIPs at the early endosome membrane
reactomeR-HSA-1660517Synthesis of PIPs at the late endosome membrane
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
pidavb3_integrin_pathwayIntegrins in angiogenesis
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP710DNA Damage Response (only ATM dependent)
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00582Joubert syndrome

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine2
iGMDRD280CYTOCHALASIN B3
iGMDRD57Chloropentafluorobenzene3
iGMDRD61Kinetin riboside1
iGMDRD152179324-69-72
iGMDRD193Fqi11
iGMDRD446LY 21832405
iGMDRD341Triacsin c3
iGMDRD420Leucascandrolide A2
iGMDRD126Tipifarnib2
iGMDRD151CHM-13
iGMDRD268Cerulenin2
iGMDRD64Parbendazole1
iGMDRD888Compound 442
iGMDRD286Nsc 6328393
iGMDRD188Piperlongumine3
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin2
iGMDRD399Selumetinib3
iGMDRD318PAC-11
iGMDRD187BRD98761
iGMDRD513BML-2592
iGMDRD121GMX17782
iGMDRD271Brefeldin A3
iGMDRD137Indisulam2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3C2A

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