SCYL3


Summary: This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SCY1 like pseudokinase 3MIM:608192Ensembl:ENSG00000000457HGNC:HGNC:19285PA1426709451q24.2

GO terms in SCYL3


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
BPIEAGO:0006468protein phosphorylation
BPNASGO:0016477cell migration
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0030027lamellipodium

Gene expression in normal tissue: SCYL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCYL3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A1
iGMDRD123Isoevodiamine2
iGMDRD945ML2143
iGMDRD85Ursolic acid2
iGMDRD61Kinetin riboside2
iGMDRD150RITA6
iGMDRD560MK-22062
iGMDRD144NSC953973
iGMDRD781Sirolimus1
iGMDRD126Tipifarnib1
iGMDRD512nutlin 35
iGMDRD889Compound 7d-cis1
iGMDRD772BRD47702
iGMDRD300Tozasertib3
iGMDRD369TGX-1152
iGMDRD524ISX-91
iGMDRD188Piperlongumine3
iGMDRD329Merck606
iGMDRD562Navitoclax5
iGMDRD434BMS-5369243
iGMDRD226ML0062
iGMDRD294Batimastat1
iGMDRD255SB2250023

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCYL3

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