SERPINB4


Summary: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serpin family B member 4MIM:600518Ensembl:ENSG00000206073HGNC:HGNC:10570PA3553918q21.33

GO terms in SERPINB4


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0010466negative regulation of peptidase activity
BPIBAGO:0010951negative regulation of endopeptidase activity
BPIEAGO:0010951negative regulation of endopeptidase activity
BPNASGO:0030162regulation of proteolysis
BPIMPGO:0042270protection from natural killer cell mediated cytotoxicity
CCIBAGO:0005615extracellular space
CCIDAGO:0005622intracellular
CCIEAGO:0005737cytoplasm
MFIPIGO:0002020protease binding
MFIBAGO:0004867serine-type endopeptidase inhibitor activity
MFIDAGO:0004867serine-type endopeptidase inhibitor activity
MFNASGO:0004867serine-type endopeptidase inhibitor activity
MFIPIGO:0019899enzyme binding

Gene expression in normal tissue: SERPINB4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SERPINB4


DatabasePathway IDPathway Des.
kegghsa05146Amoebiasis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD79Gemcitabine2
iGMDRD427ABT7372
iGMDRD546BMS-7548075
iGMDRD375GW-4058333
iGMDRD280CYTOCHALASIN B2
iGMDRD177Teniposide1
iGMDRD351GW843682X1
iGMDRD885Compound 1104
iGMDRD267Oligomycin A1
iGMDRD231Importazole4
iGMDRD705Nakiterpiosin2
iGMDRD6AM-5803
iGMDRD434BMS-5369241
iGMDRD227Fatostatin A3
iGMDRD121GMX17783
iGMDRD271Brefeldin A2
iGMDRD886Compound 1541A3
iGMDRD369TGX-1152
iGMDRD662JQ-12
iGMDRD506Fedratinib3
iGMDRD398Sepantronium2
iGMDRD562Navitoclax2
iGMDRD367Ro 28-16753
iGMDRD399Selumetinib2
iGMDRD882CIL412

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SERPINB4

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