TYK2
Summary: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tyrosine kinase 2 | MIM:176941 | Ensembl:ENSG00000105397 | HGNC:HGNC:12440 | PA37094 | 19p13.2 |
GO terms in TYK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | TAS | GO:0038155 | interleukin-23-mediated signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0070106 | interleukin-27-mediated signaling pathway |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005131 | growth hormone receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0031702 | type 1 angiotensin receptor binding |
Gene expression in normal tissue: TYK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TYK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_Prolactin | Prolactin |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| wikipathways | WP2113 | Type III interferon signaling |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4197 | The human immune response to tuberculosis |
| wikipathways | WP585 | Interferon type I signaling pathways |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8984722 | Interleukin-35 Signalling |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-9020933 | Interleukin-23 signaling |
| reactome | R-HSA-9020933 | Interleukin-23 signaling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-9020956 | Interleukin-27 signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | ifnapathway | ifn alpha signaling pathway |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | no2il12pathway | no2-dependent il-12 pathway in nk cells |
| biocarta | stat3pathway | stat3 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD220 | fumonisin B1 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD670 | ML 210 | 8 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TYK2
CLASSFICATION
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