iGMDRD551


Canonical SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

InChI: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)

InChI Key: PHXJVRSECIGDHY-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
PonatinibCHEMBL1171837 CHEMBL2105708 24826800DB08901AloneSmall Molecule



Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
7514XPO11
3845KRAS2
1387CREBBP1
5175PECAM11
7307U2AF11
25937WWTR11
7416VDAC11
2260FGFR14
2064ERBB21
3932LCK1
4088SMAD31
2322FLT36
2263FGFR29
1019CDK41
6389SDHA1
57111RAB251
4089SMAD41
4214MAP3K11
3553IL1B1
5156PDGFRA1
1938EEF21
2113ETS11
2067ERCC11
2194FASN2
1385CREB11
3815KIT8
5925RB11
4893NRAS2
25ABL131
581BAX1

Gene in drug-gene network: Network Plot

Models in Ponatinib

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