CHUK


Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
conserved helix-loop-helix ubiquitous kinaseMIM:600664Ensembl:ENSG00000213341HGNC:HGNC:1974PA2651010q24.31

GO terms in CHUK


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008384IkappaB kinase activity
MFTASGO:0008384IkappaB kinase activity
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIDAGO:0046982protein heterodimerization activity
MFIDAGO:0097110scaffold protein binding
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0008385IkappaB kinase complex
CCTASGO:0008385IkappaB kinase complex
CCISSGO:0009898cytoplasmic side of plasma membrane
CCISSGO:0035631CD40 receptor complex
CCIDAGO:0043231intracellular membrane-bounded organelle
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BPTASGO:0002756MyD88-independent toll-like receptor signaling pathway
BPIEAGO:0003009skeletal muscle contraction
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006954inflammatory response
BPTASGO:0006955immune response
BPIMPGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007252I-kappaB phosphorylation
BPIEAGO:0007266Rho protein signal transduction
BPTASGO:0009615response to virus
BPIEAGO:0009636response to toxic substance
BPIBAGO:0009653anatomical structure morphogenesis
BPTASGO:0009653anatomical structure morphogenesis
BPIEAGO:0010034response to acetate
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0032088negative regulation of NF-kappaB transcription factor activity
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0033194response to hydroperoxide
BPIBAGO:0033209tumor necrosis factor-mediated signaling pathway
BPIMPGO:0034614cellular response to reactive oxygen species
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPIMPGO:0038061NIK/NF-kappaB signaling
BPTASGO:0038061NIK/NF-kappaB signaling
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIEAGO:0042493response to drug
BPTASGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043200response to amino acid
BPTASGO:0045087innate immune response
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0050852T cell receptor signaling pathway
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051146striated muscle cell differentiation
BPTASGO:0051403stress-activated MAPK cascade
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIMPGO:0071276cellular response to cadmium ion
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0098586cellular response to virus
BPIMPGO:1902741positive regulation of interferon-alpha secretion

Gene expression in normal tissue: CHUK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHUK


DatabasePathway IDPathway Des.
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP288NLR Proteins
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP3849MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfoxopathwayFoxO family signaling
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil1pathwayIL1-mediated signaling events
pidnfkappabalternativepathwayAlternative NF-kappaB pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtnfpathwayTNF receptor signaling pathway
pidtoll_endogenous_pathwayEndogenous TLR signaling
pidtrail_pathwayTRAIL signaling pathway
netpathPathway_BCRBCR
netpathPathway_IL1IL1
netpathPathway_IL11IL11
netpathPathway_IL4IL4
netpathPathway_LeptinLeptin
netpathPathway_RAGERAGE
netpathPathway_RANKLRANKL
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
biocartaaktpathwayakt signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartaceramidepathwayceramide signaling pathway
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartail1rpathwaysignal transduction through il1r
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartanfkbpathwaynf-kb signaling pathway
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaranklpathwaybone remodeling
biocartaraspathwayras signaling pathway
biocartarnapathwaydouble stranded rna induced gene expression
biocartastresspathwaytnf/stress related signaling
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatidpathwaychaperones modulate interferon signaling pathway
biocartatollpathwaytoll-like receptor pathway
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5260271Diseases of Immune System
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5602358Diseases associated with the TLR signaling cascade
reactomeR-HSA-5602636IKBKB deficiency causes SCID
reactomeR-HSA-5603027IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
reactomeR-HSA-5603029IkBA variant leads to EDA-ID
reactomeR-HSA-5607761Dectin-1 mediated noncanonical NF-kB signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-5676590NIK-->noncanonical NF-kB signaling
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-933542TRAF6 mediated NF-kB activation
reactomeR-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
reactomeR-HSA-937039IRAK1 recruits IKK complex
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975144IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD154NSC237662
iGMDRD394BX-7952
iGMDRD901ELCPK1
iGMDRD237ABT-7513
iGMDRD219Bax channel blocker3
iGMDRD85Ursolic acid3
iGMDRD446LY 21832402
iGMDRD494Neopeltolide2
iGMDRD560MK-22066
iGMDRD599Salermide2
iGMDRD889Compound 7d-cis2
iGMDRD433Lexibulin4
iGMDRD330BRD41321
iGMDRD151CHM-14
iGMDRD524ISX-91
iGMDRD64Parbendazole5
iGMDRD369TGX-1152
iGMDRD398Sepantronium1
iGMDRD329Merck602
iGMDRD888Compound 444
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib2
iGMDRD188Piperlongumine3
iGMDRD77Itraconazole3
iGMDRD481Dactolisib1
iGMDRD105Triptolide3
iGMDRD202Curcumin4
iGMDRD270Ciclosporin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHUK

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