GRK1


Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor kinase 1MIM:180381Ensembl:ENSG00000185974HGNC:HGNC:10013PA3439113q34

GO terms in GRK1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0097381photoreceptor disc membrane
BPIEAGO:0007601visual perception
BPTASGO:0008277regulation of G-protein coupled receptor protein signaling pathway
BPTASGO:0016056rhodopsin mediated signaling pathway
BPIDAGO:0022400regulation of rhodopsin mediated signaling pathway
BPTASGO:0022400regulation of rhodopsin mediated signaling pathway
BPIMPGO:0046777protein autophosphorylation
MFTASGO:0004672protein kinase activity
MFIEAGO:0004703G-protein coupled receptor kinase activity
MFIEAGO:0005524ATP binding
MFIDAGO:0050254rhodopsin kinase activity
MFTASGO:0050254rhodopsin kinase activity

Gene expression in normal tissue: GRK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
biocartarhodopsinpathwayvisual signal transduction
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04744Phototransduction - Homo sapiens (human)
pidcone_pathwayVisual signal transduction: Cones
pidrhodopsin_pathwayVisual signal transduction: Rods
wikipathwaysWP3929Chemokine signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid1
iGMDRD193Fqi11
iGMDRD314Tanespimycin1
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin2
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD154NSC237666
iGMDRD375GW-4058332
iGMDRD330BRD41325
iGMDRD599Salermide2
iGMDRD512nutlin 31
iGMDRD424Tamatinib2
iGMDRD405PIK-751
iGMDRD483SCH-5290742
iGMDRD494Neopeltolide4
iGMDRD74Idarubicin1
iGMDRD662JQ-12
iGMDRD577BIX012942
iGMDRD506Fedratinib5
iGMDRD60Quinoclamine7
iGMDRD451Serdemetan3
iGMDRD268Cerulenin3
iGMDRD158NSC1415402
iGMDRD8024-methylfasudil2
iGMDRD171Pemetrexed2
iGMDRD434BMS-5369245
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide2
iGMDRD187BRD98764
iGMDRD294Batimastat2
iGMDRD52Rotenone4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK1

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