ITGB6


Summary: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
integrin subunit beta 6MIM:147558Ensembl:ENSG00000115221HGNC:HGNC:6161PA299602q24.2

GO terms in ITGB6


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005813centrosome
CCTASGO:0005886plasma membrane
CCIBAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCIBAGO:0008305integrin complex
CCTASGO:0008305integrin complex
CCIEAGO:0009897external side of plasma membrane
CCIBAGO:0009986cell surface
CCIDAGO:0030054cell junction
CCIBAGO:0034685integrin alphav-beta6 complex
CCIEAGO:0034685integrin alphav-beta6 complex
CCIDAGO:0043235receptor complex
BPIEAGO:0006954inflammatory response
BPTASGO:0007155cell adhesion
BPIBAGO:0007160cell-matrix adhesion
BPIEAGO:0007160cell-matrix adhesion
BPIBAGO:0007229integrin-mediated signaling pathway
BPIEAGO:0007229integrin-mediated signaling pathway
BPIBAGO:0016477cell migration
BPTASGO:0030198extracellular matrix organization
BPIBAGO:0033627cell adhesion mediated by integrin
BPIDAGO:0033627cell adhesion mediated by integrin
BPIEAGO:0038044transforming growth factor-beta secretion
BPIEAGO:0046718viral entry into host cell
MFIEAGO:0001618virus receptor activity
MFIBAGO:0005178integrin binding
MFIEAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIEAGO:0038023signaling receptor activity

Gene expression in normal tissue: ITGB6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGB6


DatabasePathway IDPathway Des.
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pidintegrin5_pathwayBeta5 beta6 beta7 and beta8 integrin cell surface interactions
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP2911miRNA targets in ECM and membrane receptors
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000178ECM proteoglycans

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD366PI-1033
iGMDRD562Navitoclax5
iGMDRD577BIX012942
iGMDRD263AACOCF36
iGMDRD131Erlotinib2
iGMDRD524ISX-92
iGMDRD138PX 123
iGMDRD202Curcumin6
iGMDRD5Tyrphostin AG 14786
iGMDRD289Parthenolide6
iGMDRD105Triptolide2
iGMDRD267Oligomycin A2
iGMDRD231Importazole2
iGMDRD52Rotenone2
iGMDRD61Kinetin riboside5
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD945ML2145
iGMDRD330BRD41321
iGMDRD409Saracatinib2
iGMDRD486Tosedostat4
iGMDRD427ABT7378
iGMDRD144NSC953972
iGMDRD560MK-22062
iGMDRD781Sirolimus2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGB6

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