PER1
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| period circadian regulator 1 | MIM:602260 | Ensembl:ENSG00000179094 | HGNC:HGNC:8845 | PA33184 | 17p13.1 |
GO terms in PER1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0002028 | regulation of sodium ion transport |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEP | GO:0007623 | circadian rhythm |
| BP | IBA | GO:0009416 | response to light stimulus |
| BP | TAS | GO:0009649 | entrainment of circadian clock |
| BP | ISS | GO:0010608 | posttranscriptional regulation of gene expression |
| BP | IBA | GO:0032922 | circadian regulation of gene expression |
| BP | IDA | GO:0032922 | circadian regulation of gene expression |
| BP | IMP | GO:0042634 | regulation of hair cycle |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043153 | entrainment of circadian clock by photoperiod |
| BP | ISS | GO:0043153 | entrainment of circadian clock by photoperiod |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | IDA | GO:0043967 | histone H4 acetylation |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0046329 | negative regulation of JNK cascade |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | ISS | GO:0070932 | histone H3 deacetylation |
| BP | ISS | GO:0097167 | circadian regulation of translation |
| BP | ISS | GO:1900015 | regulation of cytokine production involved in inflammatory response |
| BP | ISS | GO:1900744 | regulation of p38MAPK cascade |
| BP | ISS | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IBA | GO:0001222 | transcription corepressor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | ISS | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0070888 | E-box binding |
Gene expression in normal tissue: PER1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PER1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1797 | Circadian Clock |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP3355 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| pid | circadianpathway | Circadian rhythm pathway |
| reactome | R-HSA-400253 | Circadian Clock |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PER1
CLASSFICATION
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