SEARCH

HOME / SEARCH / TNIK

TNIK

Summary: Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
TRAF2 and NCK interacting kinase	MIM:610005	Ensembl:ENSG00000154310	HGNC:HGNC:30765	PA134893180	3q26.2-q26.31

Gene Categories:

DRUGGABLE GENOME TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE

GO terms in TNIK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0005856	cytoskeleton
CC	IDA	GO:0016324	apical plasma membrane
CC	IEA	GO:0055037	recycling endosome
CC	HDA	GO:0070062	extracellular exosome
BP	IBA	GO:0000165	MAPK cascade
BP	IEA	GO:0000185	activation of MAPKKK activity
BP	IMP	GO:0001934	positive regulation of protein phosphorylation
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0007010	cytoskeleton organization
BP	IDA	GO:0007256	activation of JNKK activity
BP	IMP	GO:0007256	activation of JNKK activity
BP	IBA	GO:0007346	regulation of mitotic cell cycle
BP	IEA	GO:0016055	Wnt signaling pathway
BP	IBA	GO:0023014	signal transduction by protein phosphorylation
BP	IMP	GO:0030033	microvillus assembly
BP	IDA	GO:0031532	actin cytoskeleton reorganization
BP	IBA	GO:0032147	activation of protein kinase activity
BP	IDA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0046777	protein autophosphorylation
BP	IBA	GO:0048812	neuron projection morphogenesis
BP	IDA	GO:0048814	regulation of dendrite morphogenesis
BP	IMP	GO:0072659	protein localization to plasma membrane

Gene expression in normal tissue: TNIK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNIK

Database	Pathway ID	Pathway Des.
wikipathways	WP3404	Oxidative Stress Induced Senescence
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription
pid	tnfpathway	TNF receptor signaling pathway
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2559580	Oxidative Stress Induced Senescence
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-8953897	Cellular responses to external stimuli

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD202	Curcumin	3
iGMDRD158	NSC141540	2
iGMDRD137	Indisulam	2
iGMDRD260	FQI-2	3
iGMDRD802	4-methylfasudil	3
iGMDRD705	Nakiterpiosin	2
iGMDRD6	AM-580	2
iGMDRD105	Triptolide	2
iGMDRD887	Compound 23 citrate	2
iGMDRD780	PP-30	3
iGMDRD662	JQ-1	2
iGMDRD506	Fedratinib	5
iGMDRD329	Merck60	3
iGMDRD505	Pevonedistat	5
iGMDRD451	Serdemetan	1
iGMDRD151	CHM-1	3
iGMDRD330	BRD4132	2
iGMDRD433	Lexibulin	2
iGMDRD76	Simvastatin	2
iGMDRD248	BRD4354	2
iGMDRD670	ML 210	2
iGMDRD424	Tamatinib	6
iGMDRD532	Olaparib	1
iGMDRD701	NVP-AUY922	3
iGMDRD523	Cyanoquinoline, 11	3
iGMDRD341	Triacsin c	2
iGMDRD193	Fqi1	3
iGMDRD280	CYTOCHALASIN B	2
iGMDRD123	Isoevodiamine	3
iGMDRD883	CIL55A	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNIK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.