ADAM12


Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase domain 12MIM:602714Ensembl:ENSG00000148848HGNC:HGNC:190PA2450710q26.2

GO terms in ADAM12


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004222metalloendopeptidase activity
MFIPIGO:0005515protein binding
MFTASGO:0008237metallopeptidase activity
MFIPIGO:0017124SH3 domain binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0006508proteolysis
BPIEAGO:0007155cell adhesion
BPTASGO:0007520myoblast fusion
BPTASGO:0030198extracellular matrix organization
BPIMPGO:0045766positive regulation of angiogenesis
CCIEAGO:0005576extracellular region
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: ADAM12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAM12


DatabasePathway IDPathway Des.
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidnotch_pathwayNotch signaling pathway
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-8941237Invadopodia formation
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 122
iGMDRD77Itraconazole2
iGMDRD318PAC-12
iGMDRD434BMS-5369241
iGMDRD289Parthenolide2
iGMDRD6AM-5802
iGMDRD888Compound 441
iGMDRD577BIX012942
iGMDRD82Quiflapon1
iGMDRD64Parbendazole4
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A2
iGMDRD248BRD43543
iGMDRD889Compound 7d-cis5
iGMDRD330BRD41323
iGMDRD126Tipifarnib2
iGMDRD483SCH-5290742
iGMDRD427ABT7373
iGMDRD560MK-22063
iGMDRD61Kinetin riboside3
iGMDRD193Fqi11
iGMDRD499PDMP1
iGMDRD201SKI II2
iGMDRD341Triacsin c3
iGMDRD883CIL55A1
iGMDRD280CYTOCHALASIN B2
iGMDRD394BX-7952
iGMDRD297Austocystin D3
iGMDRD901ELCPK3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAM12

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