BAX
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 associated X, apoptosis regulator | MIM:600040 | Ensembl:ENSG00000087088 | HGNC:HGNC:959 | PA25269 | 19q13.33 |
GO terms in BAX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | IBA | GO:0015267 | channel activity |
| MF | IDA | GO:0015267 | channel activity |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0051087 | chaperone binding |
| MF | IDA | GO:0051434 | BH3 domain binding |
| MF | IPI | GO:0051434 | BH3 domain binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IDA | GO:0005757 | mitochondrial permeability transition pore complex |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0046930 | pore complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071944 | cell periphery |
| CC | IDA | GO:0097136 | Bcl-2 family protein complex |
| CC | IDA | GO:0097144 | BAX complex |
| BP | IEA | GO:0001541 | ovarian follicle development |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001777 | T cell homeostatic proliferation |
| BP | IEA | GO:0001782 | B cell homeostasis |
| BP | IDA | GO:0001783 | B cell apoptotic process |
| BP | IEA | GO:0001822 | kidney development |
| BP | IBA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | IDA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | TAS | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IEA | GO:0001974 | blood vessel remodeling |
| BP | IEA | GO:0002262 | myeloid cell homeostasis |
| BP | IEA | GO:0002352 | B cell negative selection |
| BP | IEA | GO:0002358 | B cell homeostatic proliferation |
| BP | IEA | GO:0002904 | positive regulation of B cell apoptotic process |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006687 | glycosphingolipid metabolic process |
| BP | IEA | GO:0006808 | regulation of nitrogen utilization |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IEA | GO:0007281 | germ cell development |
| BP | IBA | GO:0008053 | mitochondrial fusion |
| BP | IDA | GO:0008053 | mitochondrial fusion |
| BP | IC | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IBA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IDA | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
| BP | IDA | GO:0008637 | apoptotic mitochondrial changes |
| BP | IEA | GO:0009566 | fertilization |
| BP | IDA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0009651 | response to salt stress |
| BP | IDA | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| BP | IEA | GO:0010332 | response to gamma radiation |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0021854 | hypothalamus development |
| BP | IEA | GO:0021987 | cerebral cortex development |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032461 | positive regulation of protein oligomerization |
| BP | TAS | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
| BP | IEA | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| BP | IDA | GO:0032976 | release of matrix enzymes from mitochondria |
| BP | IEA | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0033599 | regulation of mammary gland epithelial cell proliferation |
| BP | TAS | GO:0034620 | cellular response to unfolded protein |
| BP | IEA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035234 | ectopic germ cell programmed cell death |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043496 | regulation of protein homodimerization activity |
| BP | IPI | GO:0043497 | regulation of protein heterodimerization activity |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IDA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IDA | GO:0043653 | mitochondrial fragmentation involved in apoptotic process |
| BP | IEA | GO:0045136 | development of secondary sexual characteristics |
| BP | IEA | GO:0046666 | retinal cell programmed cell death |
| BP | IEA | GO:0048087 | positive regulation of developmental pigmentation |
| BP | IEA | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | IEA | GO:0048515 | spermatid differentiation |
| BP | IEA | GO:0048597 | post-embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0048678 | response to axon injury |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IEA | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051402 | neuron apoptotic process |
| BP | IDA | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IEA | GO:0060011 | Sertoli cell proliferation |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0060058 | positive regulation of apoptotic process involved in mammary gland involution |
| BP | IEA | GO:0060068 | vagina development |
| BP | IMP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEA | GO:0070242 | thymocyte apoptotic process |
| BP | IEA | GO:0070584 | mitochondrion morphogenesis |
| BP | IEA | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| BP | IDA | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IMP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IDA | GO:0097190 | apoptotic signaling pathway |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IDA | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | IEA | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| BP | IMP | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response |
| BP | TAS | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| BP | IEA | GO:1902262 | apoptotic process involved in blood vessel morphogenesis |
| BP | IEA | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis |
| BP | IEA | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| BP | IMP | GO:1902512 | positive regulation of apoptotic DNA fragmentation |
| BP | TAS | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| BP | IDA | GO:1990117 | B cell receptor apoptotic signaling pathway |
| BP | IEA | GO:2001234 | negative regulation of apoptotic signaling pathway |
| BP | IEA | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IMP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: BAX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111457 | Release of apoptotic factors from the mitochondria |
| reactome | R-HSA-114294 | Activation, translocation and oligomerization of BAX |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9603505 | NTRK3 as a dependence receptor |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1742 | TP53 Network |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2815 | Mammary gland development pathway - Involution (Stage 4 of 4) |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP707 | DNA Damage Response |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_IL5 | IL5 |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD464 | RAF265 | 1 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD265 | Dacarbazine | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD727 | Alpelisib | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD714 | BRD-K17060750 | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD615 | BRD-K02251932 | 1 |
| iGMDRD873 | BRD8899 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD512 | nutlin 3 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAX
CLASSFICATION
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