CTBP2
Summary: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-terminal binding protein 2 | MIM:602619 | Ensembl:ENSG00000175029 | HGNC:HGNC:2495 | PA26996 | 10q26.13 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in CTBP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0019079 | viral genome replication |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway |
| BP | ISS | GO:0050872 | white fat cell differentiation |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0017053 | transcriptional repressor complex |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0045202 | synapse |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0051287 | NAD binding |
Gene expression in normal tissue: CTBP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTBP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5339700 | TCF7L2 mutants don't bind CTBP |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTBP2
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