LGR5
Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
leucine rich repeat containing G protein-coupled receptor 5 | MIM:606667 | Ensembl:ENSG00000139292 | HGNC:HGNC:4504 | PA28894 | 12q21.1 |
GO terms in LGR5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005886 | plasma membrane |
CC | IBA | GO:0005887 | integral component of plasma membrane |
CC | IDA | GO:0005887 | integral component of plasma membrane |
CC | IDA | GO:0032588 | trans-Golgi network membrane |
BP | IEA | GO:0001942 | hair follicle development |
BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | IBA | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
BP | IBA | GO:0007190 | activation of adenylate cyclase activity |
BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
BP | IEA | GO:0009994 | oocyte differentiation |
BP | IEA | GO:0042127 | regulation of cell proliferation |
BP | IEA | GO:0048839 | inner ear development |
BP | IDA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
BP | IEA | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis |
MF | IDA | GO:0004888 | transmembrane signaling receptor activity |
MF | IDA | GO:0004930 | G-protein coupled receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008528 | G-protein coupled peptide receptor activity |
MF | IEA | GO:0016500 | protein-hormone receptor activity |
Gene expression in normal tissue: LGR5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LGR5
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-195721 | Signaling by WNT |
reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
reactome | R-HSA-4641263 | Regulation of FZD by ubiquitination |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD886 | Compound 1541A | 3 |
iGMDRD147 | Prima-1 | 1 |
iGMDRD60 | Quinoclamine | 1 |
iGMDRD888 | Compound 44 | 2 |
iGMDRD506 | Fedratinib | 3 |
iGMDRD562 | Navitoclax | 2 |
iGMDRD780 | PP-30 | 6 |
iGMDRD398 | Sepantronium | 6 |
iGMDRD286 | Nsc 632839 | 3 |
iGMDRD367 | Ro 28-1675 | 3 |
iGMDRD871 | BRD6368 | 4 |
iGMDRD887 | Compound 23 citrate | 4 |
iGMDRD441 | TW 37 | 2 |
iGMDRD870 | BRD63610 | 3 |
iGMDRD6 | AM-580 | 3 |
iGMDRD270 | Ciclosporin | 1 |
iGMDRD211 | (1S,3R)-RSL3 | 3 |
iGMDRD280 | CYTOCHALASIN B | 6 |
iGMDRD679 | Bistramide A | 6 |
iGMDRD781 | Sirolimus | 4 |
iGMDRD779 | PRL-3 Inhibitor I | 2 |
iGMDRD670 | ML 210 | 3 |
iGMDRD512 | nutlin 3 | 2 |
iGMDRD772 | BRD4770 | 2 |
iGMDRD84 | Lovastatin acid | 1 |
iGMDRD126 | Tipifarnib | 7 |
iGMDRD307 | Manumycin A | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LGR5