MYB


Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MYB proto-oncogene, transcription factorMIM:189990Ensembl:ENSG00000118513HGNC:HGNC:7545PA313456q23.3

Gene Categories:

HISTONE MODIFICATION

GO terms in MYB


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000278mitotic cell cycle
BPIEAGO:0001666response to hypoxia
BPIMPGO:0006338chromatin remodeling
BPNASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0032967positive regulation of collagen biosynthetic process
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIMPGO:0045624positive regulation of T-helper cell differentiation
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIMPGO:0051571positive regulation of histone H3-K4 methylation
BPIMPGO:0051574positive regulation of histone H3-K9 methylation
BPIEAGO:0060252positive regulation of glial cell proliferation
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0071636positive regulation of transforming growth factor beta production
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
BPIEAGO:1904899positive regulation of hepatic stellate cell proliferation
BPIEAGO:2000491positive regulation of hepatic stellate cell activation
BPIEAGO:2000845positive regulation of testosterone secretion
CCTASGO:0005654nucleoplasm
CCNASGO:0016363nuclear matrix
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: MYB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYB


DatabasePathway IDPathway Des.
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
pidcmyb_pathwayC-MYB transcription factor network
pidhes_heypathwayNotch-mediated HES/HEY network
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil4_2pathwayIL4-mediated signaling events
netpathPathway_ProlactinProlactin
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP3297EV release from cardiac cells and their functional effects
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP4105Transcriptional regulation by RUNX1
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD494Neopeltolide2
iGMDRD79Gemcitabine2
iGMDRD330BRD41323
iGMDRD889Compound 7d-cis1
iGMDRD420Leucascandrolide A2
iGMDRD248BRD43545
iGMDRD369TGX-1152
iGMDRD23Gossypol3
iGMDRD268Cerulenin1
iGMDRD524ISX-92
iGMDRD414MST-3122
iGMDRD286Nsc 6328391
iGMDRD871BRD63682
iGMDRD100Zebularine1
iGMDRD888Compound 442
iGMDRD329Merck601
iGMDRD577BIX012943
iGMDRD562Navitoclax3
iGMDRD105Triptolide2
iGMDRD289Parthenolide2
iGMDRD870BRD636102
iGMDRD231Importazole2
iGMDRD52Rotenone2
iGMDRD267Oligomycin A3
iGMDRD271Brefeldin A2
iGMDRD474Avrainvillamide2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYB

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