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MYB

Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
MYB proto-oncogene, transcription factor	MIM:189990	Ensembl:ENSG00000118513	HGNC:HGNC:7545	PA31345	6q23.3

Gene Categories:

HISTONE MODIFICATION

GO terms in MYB

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IBA	GO:0000278	mitotic cell cycle
BP	IEA	GO:0001666	response to hypoxia
BP	IMP	GO:0006338	chromatin remodeling
BP	NAS	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	IEA	GO:0032967	positive regulation of collagen biosynthetic process
BP	IEA	GO:0043525	positive regulation of neuron apoptotic process
BP	IMP	GO:0045624	positive regulation of T-helper cell differentiation
BP	IMP	GO:0045892	negative regulation of transcription, DNA-templated
BP	IBA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	NAS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048661	positive regulation of smooth muscle cell proliferation
BP	IMP	GO:0051571	positive regulation of histone H3-K4 methylation
BP	IMP	GO:0051574	positive regulation of histone H3-K9 methylation
BP	IEA	GO:0060252	positive regulation of glial cell proliferation
BP	IEA	GO:0070301	cellular response to hydrogen peroxide
BP	IEA	GO:0071300	cellular response to retinoic acid
BP	IEA	GO:0071636	positive regulation of transforming growth factor beta production
BP	TAS	GO:1902036	regulation of hematopoietic stem cell differentiation
BP	IEA	GO:1904899	positive regulation of hepatic stellate cell proliferation
BP	IEA	GO:2000491	positive regulation of hepatic stellate cell activation
BP	IEA	GO:2000845	positive regulation of testosterone secretion
CC	TAS	GO:0005654	nucleoplasm
CC	NAS	GO:0016363	nuclear matrix
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IC	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: MYB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYB

Database	Pathway ID	Pathway Des.
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
pid	ap1_pathway	AP-1 transcription factor network
pid	cmyb_pathway	C-MYB transcription factor network
pid	hes_heypathway	Notch-mediated HES/HEY network
pid	il2_pi3kpathway	IL2 signaling events mediated by PI3K
pid	il4_2pathway	IL4-mediated signaling events
netpath	Pathway_Prolactin	Prolactin
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2064	Neural Crest Differentiation
wikipathways	WP2849	Hematopoietic Stem Cell Differentiation
wikipathways	WP3297	EV release from cardiac cells and their functional effects
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP4105	Transcriptional regulation by RUNX1
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9018519	Estrogen-dependent gene expression
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD945	ML214	3
iGMDRD494	Neopeltolide	2
iGMDRD79	Gemcitabine	2
iGMDRD330	BRD4132	3
iGMDRD889	Compound 7d-cis	1
iGMDRD420	Leucascandrolide A	2
iGMDRD248	BRD4354	5
iGMDRD369	TGX-115	2
iGMDRD23	Gossypol	3
iGMDRD268	Cerulenin	1
iGMDRD524	ISX-9	2
iGMDRD414	MST-312	2
iGMDRD286	Nsc 632839	1
iGMDRD871	BRD6368	2
iGMDRD100	Zebularine	1
iGMDRD888	Compound 44	2
iGMDRD329	Merck60	1
iGMDRD577	BIX01294	3
iGMDRD562	Navitoclax	3
iGMDRD105	Triptolide	2
iGMDRD289	Parthenolide	2
iGMDRD870	BRD63610	2
iGMDRD231	Importazole	2
iGMDRD52	Rotenone	2
iGMDRD267	Oligomycin A	3
iGMDRD271	Brefeldin A	2
iGMDRD474	Avrainvillamide	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYB

SITE

DATATYPES

CLASSFICATION

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