PTK7


Summary: This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine kinase 7 (inactive)MIM:601890Ensembl:ENSG00000112655HGNC:HGNC:9618PA339616p21.1

GO terms in PTK7


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFNASGO:1904929coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
BPIBAGO:0001736establishment of planar polarity
BPIEAGO:0001736establishment of planar polarity
BPIEAGO:0003281ventricular septum development
BPIBAGO:0003401axis elongation
BPIEAGO:0003401axis elongation
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0007155cell adhesion
BPTASGO:0007165signal transduction
BPIMPGO:0010976positive regulation of neuron projection development
BPIMPGO:0016477cell migration
BPIMPGO:0031532actin cytoskeleton reorganization
BPIEAGO:0042060wound healing
BPIEAGO:0045198establishment of epithelial cell apical/basal polarity
BPIEAGO:0060026convergent extension
BPIBAGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPIEAGO:0060484lung-associated mesenchyme development
BPIEAGO:0060976coronary vasculature development
BPIMPGO:0071300cellular response to retinoic acid
BPIEAGO:0090103cochlea morphogenesis
BPIEAGO:0090179planar cell polarity pathway involved in neural tube closure
CCIEAGO:0005887integral component of plasma membrane
CCIBAGO:0005911cell-cell junction
CCIDAGO:0005911cell-cell junction
CCHDAGO:0005925focal adhesion

Gene expression in normal tissue: PTK7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTK7


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7512
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD634SCHEMBL26080412
iGMDRD394BX-7951
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B4
iGMDRD123Isoevodiamine2
iGMDRD297Austocystin D2
iGMDRD772BRD47702
iGMDRD512nutlin 33
iGMDRD126Tipifarnib2
iGMDRD494Neopeltolide2
iGMDRD546BMS-7548072
iGMDRD150RITA8
iGMDRD562Navitoclax2
iGMDRD887Compound 23 citrate2
iGMDRD188Piperlongumine4
iGMDRD286Nsc 6328394
iGMDRD356PNU-746542
iGMDRD23Gossypol2
iGMDRD5Tyrphostin AG 14782
iGMDRD213SMR0000686502
iGMDRD441TW 372
iGMDRD434BMS-5369242
iGMDRD171Pemetrexed3
iGMDRD105Triptolide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTK7

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