REL
Summary: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| REL proto-oncogene, NF-kB subunit | MIM:164910 | Ensembl:ENSG00000162924 | HGNC:HGNC:9954 | PA34321 | 2p16.1 |
GO terms in REL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IMP | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0033256 | I-kappaB/NF-kappaB complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IDA | GO:0032688 | negative regulation of interferon-beta production |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0038061 | NIK/NF-kappaB signaling |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:1901215 | negative regulation of neuron death |
Gene expression in normal tissue: REL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in REL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TNFalpha | TNFalpha |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in REL
CLASSFICATION
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