S100A9
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| S100 calcium binding protein A9 | MIM:123886 | Ensembl:ENSG00000163220 | HGNC:HGNC:10499 | PA34911 | 1q21.3 |
GO terms in S100A9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008017 | microtubule binding |
| MF | TAS | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016209 | antioxidant activity |
| MF | TAS | GO:0035662 | Toll-like receptor 4 binding |
| MF | TAS | GO:0050544 | arachidonic acid binding |
| MF | TAS | GO:0050786 | RAGE receptor binding |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0001816 | cytokine production |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IDA | GO:0002523 | leukocyte migration involved in inflammatory response |
| BP | IEA | GO:0002793 | positive regulation of peptide secretion |
| BP | IEA | GO:0006417 | regulation of translation |
| BP | IDA | GO:0006914 | autophagy |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0014002 | astrocyte development |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | IEA | GO:0030194 | positive regulation of blood coagulation |
| BP | TAS | GO:0030307 | positive regulation of cell growth |
| BP | IDA | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0031532 | actin cytoskeleton reorganization |
| BP | TAS | GO:0032119 | sequestering of zinc ion |
| BP | TAS | GO:0032602 | chemokine production |
| BP | IDA | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation |
| BP | IDA | GO:0035821 | modification of morphology or physiology of other organism |
| BP | TAS | GO:0042742 | defense response to bacterium |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045113 | regulation of integrin biosynthetic process |
| BP | IDA | GO:0050729 | positive regulation of inflammatory response |
| BP | TAS | GO:0050832 | defense response to fungus |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051493 | regulation of cytoskeleton organization |
| BP | IDA | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| BP | IDA | GO:0070488 | neutrophil aggregation |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | IDA | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: S100A9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100A9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-5686938 | Regulation of TLR by endogenous ligand |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6799990 | Metal sequestration by antimicrobial proteins |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD434 | BMS-536924 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A9
CLASSFICATION
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