XPO5


Summary: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
exportin 5MIM:607845Ensembl:ENSG00000124571HGNC:HGNC:17675PA1349792146p21.1

Gene Categories:

TRANSPORTER

GO terms in XPO5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000049tRNA binding
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFTASGO:0003723RNA binding
MFIDAGO:0003729mRNA binding
MFIBAGO:0005049nuclear export signal receptor activity
MFIMPGO:0005049nuclear export signal receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008536Ran GTPase binding
MFIPIGO:0008536Ran GTPase binding
MFIEAGO:0008565protein transporter activity
MFIDAGO:0070883pre-miRNA binding
MFIDAGO:0070883pre-miRNA binding
MFNASGO:0070883pre-miRNA binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0035068micro-ribonucleoprotein complex
CCIDAGO:0042272nuclear RNA export factor complex
CCIBAGO:0042565RNA nuclear export complex
CCIDAGO:0042565RNA nuclear export complex
BPIBAGO:0006405RNA export from nucleus
BPIDAGO:0006611protein export from nucleus
BPTASGO:0010586miRNA metabolic process
BPIDAGO:0035281pre-miRNA export from nucleus
BPIMPGO:0035281pre-miRNA export from nucleus
BPNASGO:0035281pre-miRNA export from nucleus
BPIBAGO:0046825regulation of protein export from nucleus
BPIDAGO:1900370positive regulation of RNA interference

Gene expression in normal tissue: XPO5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XPO5


DatabasePathway IDPathway Des.
reactomeR-HSA-203927MicroRNA (miRNA) biogenesis
reactomeR-HSA-211000Gene Silencing by RNA
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa03013RNA transport - Homo sapiens (human)
wikipathwaysWP2338miRNA Biogenesis
wikipathwaysWP2805RNA interference

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD121GMX17783
iGMDRD158NSC1415402
iGMDRD870BRD636106
iGMDRD187BRD98762
iGMDRD885Compound 1104
iGMDRD434BMS-5369241
iGMDRD105Triptolide2
iGMDRD780PP-302
iGMDRD577BIX012946
iGMDRD329Merck606
iGMDRD882CIL412
iGMDRD887Compound 23 citrate5
iGMDRD524ISX-93
iGMDRD60Quinoclamine3
iGMDRD246NPC262
iGMDRD147Prima-13
iGMDRD886Compound 1541A3
iGMDRD690PRIMA-1MET2
iGMDRD420Leucascandrolide A3
iGMDRD772BRD47702
iGMDRD248BRD43541
iGMDRD425ERASTIN2
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD781Sirolimus5
iGMDRD945ML2142
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD634SCHEMBL26080413
iGMDRD394BX-7951
iGMDRD679Bistramide A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XPO5

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