ELAVL1
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603466 Ensembl IDEnsembl:ENSG00000066044 HGNC IDHGNC:HGNC:3312 PHARMGKB IDPA27740 Map Location19p13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ELAVL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: ELAVL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ELAVL1
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
netpath | Pathway_Gastrin | Gastrin |
wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
wikipathways | WP2853 | Endoderm Differentiation |
wikipathways | WP3527 | Preimplantation Embryo |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ELAVL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |