ELAVL1

Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameELAV like RNA binding protein 1
OMIM IDMIM:603466
Ensembl IDEnsembl:ENSG00000066044
HGNC IDHGNC:HGNC:3312
PHARMGKB IDPA27740
Map Location19p13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in ELAVL1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
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Gene expression in normal tissue: ELAVL1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 53undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 22BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 11

Gene-drug pathway distribution

undefined22Apoptosis regulation2PI3K/MTOR signaling2DNA replication1Leukocyte transendothelial migration1ERK MAPK signaling1Longevity regulating pathway1

Pathways in ELAVL1


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Database
Pathway ID
Pathway Des.
kegg hsa04152 AMPK signaling pathway - Homo sapiens (human)
kegg hsa04657 IL-17 signaling pathway - Homo sapiens (human)
netpath Pathway_Gastrin Gastrin
wikipathways WP1403 AMP-activated Protein Kinase (AMPK) Signaling
wikipathways WP2853 Endoderm Differentiation
wikipathways WP3527 Preimplantation Embryo
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD154 NSC23766 6
iGMDRD634 SCHEMBL2608041 2
iGMDRD280 CYTOCHALASIN B 3
iGMDRD394 BX-795 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ELAVL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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