ESR2


Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
estrogen receptor 2MIM:601663Ensembl:ENSG00000140009HGNC:HGNC:3468PA2788614q23.2-q23.3

GO terms in ESR2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0003707steroid hormone receptor activity
MFTASGO:0003713transcription coactivator activity
MFNASGO:0004879nuclear receptor activity
MFISSGO:0005496steroid binding
MFTASGO:0005496steroid binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019899enzyme binding
MFTASGO:0030284estrogen receptor activity
MFIDAGO:0034056estrogen response element binding
MFIDAGO:0038052RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
MFIPIGO:0042802identical protein binding
MFNASGO:0048019receptor antagonist activity
CCIEAGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPNASGO:0030308negative regulation of cell growth
BPTASGO:0030520intracellular estrogen receptor signaling pathway
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:1900116extracellular negative regulation of signal transduction

Gene expression in normal tissue: ESR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ESR2


DatabasePathway IDPathway Des.
pharmgkbPA145011120Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP34Ovarian Infertility Genes
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006931Signaling by Nuclear Receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD870BRD636103
iGMDRD52Rotenone3
iGMDRD441TW 371
iGMDRD782DC-45-A26
iGMDRD6AM-5803
iGMDRD271Brefeldin A3
iGMDRD524ISX-93
iGMDRD322FK 8663
iGMDRD23Gossypol5
iGMDRD82Quiflapon3
iGMDRD300Tozasertib1
iGMDRD562Navitoclax3
iGMDRD398Sepantronium2
iGMDRD888Compound 443
iGMDRD577BIX012944
iGMDRD871BRD63683
iGMDRD367Ro 28-16753
iGMDRD494Neopeltolide3
iGMDRD427ABT7379
iGMDRD560MK-22061
iGMDRD420Leucascandrolide A2
iGMDRD248BRD43543
iGMDRD579PF7503
iGMDRD599Salermide6
iGMDRD889Compound 7d-cis3
iGMDRD330BRD41323
iGMDRD375GW-4058333
iGMDRD351GW843682X6
iGMDRD718Pyrvinium pamoate3
iGMDRD71Sparfosic acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ESR2

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