PAPPA
Summary: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pappalysin 1 | MIM:176385 | Ensembl:ENSG00000182752 | HGNC:HGNC:8602 | PA32935 | 9q33.1 |
GO terms in PAPPA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006508 | proteolysis |
| BP | NAS | GO:0007565 | female pregnancy |
| BP | IEA | GO:0032354 | response to follicle-stimulating hormone |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| CC | IDA | GO:0005576 | extracellular region |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| MF | EXP | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | NAS | GO:0008237 | metallopeptidase activity |
| MF | NAS | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: PAPPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAPPA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD670 | ML 210 | 6 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAPPA
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