PIP5K1A
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4-phosphate 5-kinase type 1 alpha | MIM:603275 | Ensembl:ENSG00000143398 | HGNC:HGNC:8994 | PA33327 | 1q21.3 |
GO terms in PIP5K1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006650 | glycerophospholipid metabolic process |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | TAS | GO:0006909 | phagocytosis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0008654 | phospholipid biosynthetic process |
| BP | IEA | GO:0010761 | fibroblast migration |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | NAS | GO:0016477 | cell migration |
| BP | TAS | GO:0030216 | keratinocyte differentiation |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IMP | GO:0048041 | focal adhesion assembly |
| BP | IMP | GO:0060326 | cell chemotaxis |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0090630 | activation of GTPase activity |
| BP | IMP | GO:0097178 | ruffle assembly |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | TAS | GO:0016607 | nuclear speck |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0032587 | ruffle membrane |
| MF | TAS | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | TAS | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | IDA | GO:0019900 | kinase binding |
| MF | TAS | GO:0052810 | 1-phosphatidylinositol-5-kinase activity |
| MF | TAS | GO:0052811 | 1-phosphatidylinositol-3-phosphate 4-kinase activity |
| MF | TAS | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity |
Gene expression in normal tissue: PIP5K1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIP5K1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | arf6downstreampathway | Arf6 downstream pathway |
| pid | arf_3pathway | Arf1 pathway |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | rhopathway | rho cell motility signaling pathway |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| netpath | Pathway_BCR | BCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 6 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD150 | RITA | 3 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIP5K1A
CLASSFICATION
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