RCBTB2


Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RCC1 and BTB domain containing protein 2MIM:603524Ensembl:ENSG00000136161HGNC:HGNC:1914PA2645013q14.2

GO terms in RCBTB2


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0001669acrosomal vesicle
MFTASGO:0005087Ran guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: RCBTB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RCBTB2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B1
iGMDRD201SKI II1
iGMDRD446LY 21832402
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-74
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD546BMS-7548072
iGMDRD424Tamatinib1
iGMDRD484Pluripotin2
iGMDRD126Tipifarnib8
iGMDRD772BRD47701
iGMDRD579PF7501
iGMDRD889Compound 7d-cis2
iGMDRD42Vorinostat2
iGMDRD23Gossypol1
iGMDRD82Quiflapon1
iGMDRD74Idarubicin2
iGMDRD871BRD63682
iGMDRD100Zebularine2
iGMDRD329Merck603
iGMDRD782DC-45-A22
iGMDRD434BMS-5369241
iGMDRD705Nakiterpiosin2
iGMDRD105Triptolide3
iGMDRD213SMR0000686501
iGMDRD52Rotenone1
iGMDRD441TW 372
iGMDRD481Dactolisib1
iGMDRD121GMX17781
iGMDRD271Brefeldin A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RCBTB2

​​​​