BMP2K
Summary: This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BMP2 inducible kinase | MIM:617648 | Ensembl:ENSG00000138756 | HGNC:HGNC:18041 | PA134992822 | 4q21.21 |
GO terms in BMP2K
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0019208 | phosphatase regulator activity |
| MF | IBA | GO:0035612 | AP-2 adaptor complex binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0030100 | regulation of endocytosis |
| BP | IBA | GO:0030500 | regulation of bone mineralization |
| BP | IBA | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IEA | GO:0050790 | regulation of catalytic activity |
| BP | IBA | GO:2000369 | regulation of clathrin-dependent endocytosis |
Gene expression in normal tissue: BMP2K
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMP2K
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD246 | NPC26 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMP2K
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