CDX2


Summary: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caudal type homeobox 2MIM:600297Ensembl:ENSG00000165556HGNC:HGNC:1806PA2635213q12.2

GO terms in CDX2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003714transcription corepressor activity
MFIDAGO:0008327methyl-CpG binding
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001568blood vessel development
BPIEAGO:0001829trophectodermal cell differentiation
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0008333endosome to lysosome transport
BPIBAGO:0009887animal organ morphogenesis
BPTASGO:0009887animal organ morphogenesis
BPIBAGO:0009948anterior/posterior axis specification
BPISSGO:0014807regulation of somitogenesis
BPIBAGO:0030154cell differentiation
BPIEAGO:0035019somatic stem cell population maintenance
BPIEAGO:0045197establishment or maintenance of epithelial cell apical/basal polarity
BPIEAGO:0045597positive regulation of cell differentiation
BPIEAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0060575intestinal epithelial cell differentiation
BPIEAGO:0060711labyrinthine layer development
CCIEAGO:0000794condensed nuclear chromosome
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0017053transcriptional repressor complex

Gene expression in normal tissue: CDX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDX2


DatabasePathway IDPathway Des.
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400508Incretin synthesis, secretion, and inactivation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3382POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
wikipathwaysWP3527Preimplantation Embryo
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD307Manumycin A2
iGMDRD889Compound 7d-cis2
iGMDRD512nutlin 32
iGMDRD446LY 21832401
iGMDRD341Triacsin c1
iGMDRD61Kinetin riboside3
iGMDRD718Pyrvinium pamoate4
iGMDRD280CYTOCHALASIN B1
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD202Curcumin1
iGMDRD137Indisulam3
iGMDRD255SB2250023
iGMDRD289Parthenolide3
iGMDRD6AM-5801
iGMDRD267Oligomycin A2
iGMDRD213SMR0000686501
iGMDRD441TW 372
iGMDRD872BRD71376
iGMDRD887Compound 23 citrate1
iGMDRD399Selumetinib9
iGMDRD367Ro 28-16751
iGMDRD871BRD63681
iGMDRD286Nsc 6328393
iGMDRD188Piperlongumine3
iGMDRD398Sepantronium2
iGMDRD506Fedratinib2
iGMDRD888Compound 443
iGMDRD60Quinoclamine1
iGMDRD300Tozasertib1
iGMDRD524ISX-91
iGMDRD23Gossypol2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDX2

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