FBXO43
Summary: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| F-box protein 43 | MIM:609110 | Ensembl:ENSG00000156509 | HGNC:HGNC:28521 | PA134913061 | 8q22.2 |
Gene Categories:
TUMOR SUPPRESSORGO terms in FBXO43
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005634 | nucleus |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0045835 | negative regulation of meiotic nuclear division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
Gene expression in normal tissue: FBXO43
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FBXO43
CLASSFICATION
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