NOTCH2
Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| notch 2 | MIM:600275 | Ensembl:ENSG00000134250 | HGNC:HGNC:7882 | PA31684 | 1p12 |
GO terms in NOTCH2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001709 | cell fate determination |
| BP | ISS | GO:0002315 | marginal zone B cell differentiation |
| BP | IMP | GO:0003184 | pulmonary valve morphogenesis |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | NAS | GO:0007275 | multicellular organism development |
| BP | NAS | GO:0007399 | nervous system development |
| BP | IEP | GO:0009887 | animal organ morphogenesis |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | TAS | GO:0019827 | stem cell population maintenance |
| BP | TAS | GO:0030097 | hemopoiesis |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0045967 | negative regulation of growth rate |
| BP | IDA | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IMP | GO:0046849 | bone remodeling |
| BP | IMP | GO:0060413 | atrial septum morphogenesis |
| BP | IC | GO:0061314 | Notch signaling involved in heart development |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:2001204 | regulation of osteoclast development |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: NOTCH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOTCH2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Notch | Notch |
| pid | notch_pathway | Notch signaling pathway |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2786 | Pre-NOTCH Expression and Processing |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription |
| reactome | R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-5083630 | Defective LFNG causes SCDO3 |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD356 | PNU-74654 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD525 | Gamma secretase inhibitor | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOTCH2
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