PLCG1
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase C gamma 1 | MIM:172420 | Ensembl:ENSG00000124181 | HGNC:HGNC:9065 | PA33392 | 20q12 |
GO terms in PLCG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0009395 | phospholipid catabolic process |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0019722 | calcium-mediated signaling |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IDA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IMP | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IMP | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| BP | IMP | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| CC | IDA | GO:0001726 | ruffle |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0042995 | cell projection |
| MF | IDA | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004629 | phospholipase C activity |
| MF | IPI | GO:0005168 | neurotrophin TRKA receptor binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IEA | GO:0035254 | glutamate receptor binding |
Gene expression in normal tissue: PLCG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | epopathway | EPO signaling pathway |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | s1p_s1p4_pathway | S1P4 pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2526 | PDGF Pathway |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3958 | GPR40 Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1251932 | PLCG1 events in ERBB2 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167021 | PLC-gamma1 signalling |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-212718 | EGFR interacts with phospholipase C-gamma |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-418890 | Role of second messengers in netrin-1 signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 |
| reactome | R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 |
| reactome | R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 |
| reactome | R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655291 | Signaling by FGFR4 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9026527 | Activated NTRK2 signals through PLCG1 |
| reactome | R-HSA-9026527 | Activated NTRK2 signals through PLCG1 |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | cxcr4pathway | cxcr4 signaling pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | epopathway | epo signaling pathway |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | ionpathway | ionomycin and phorbal ester signaling pathway |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | plcpathway | phospholipase c signaling pathway |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD522 | ML-030 | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 8 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCG1
CLASSFICATION
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