PLK2
Summary: The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polo like kinase 2 | MIM:607023 | Ensembl:ENSG00000145632 | HGNC:HGNC:19699 | PA134940798 | 5q11.2 |
GO terms in PLK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0043008 | ATP-dependent protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| CC | IEA | GO:0000785 | chromatin |
| CC | ISS | GO:0005622 | intracellular |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005814 | centriole |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0030425 | dendrite |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IDA | GO:0007052 | mitotic spindle organization |
| BP | ISS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | ISS | GO:0007265 | Ras protein signal transduction |
| BP | ISS | GO:0007613 | memory |
| BP | IDA | GO:0010508 | positive regulation of autophagy |
| BP | IEA | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032486 | Rap protein signal transduction |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0045732 | positive regulation of protein catabolic process |
| BP | IDA | GO:0046599 | regulation of centriole replication |
| BP | IMP | GO:0046599 | regulation of centriole replication |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | ISS | GO:0060291 | long-term synaptic potentiation |
| BP | ISS | GO:0060292 | long term synaptic depression |
| BP | IEA | GO:0061000 | negative regulation of dendritic spine development |
| BP | IEA | GO:0071866 | negative regulation of apoptotic process in bone marrow |
| BP | IEA | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | IEA | GO:2000773 | negative regulation of cellular senescence |
Gene expression in normal tissue: PLK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3804 | TP53 Regulates Transcription of Cell Cycle Genes |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD150 | RITA | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLK2
CLASSFICATION
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