RANBP9


Summary: This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAN binding protein 9MIM:603854Ensembl:ENSG00000010017HGNC:HGNC:13727PA342156p23

GO terms in RANBP9


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFTASGO:0008536Ran GTPase binding
MFIPIGO:0019899enzyme binding
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005875microtubule associated complex
CCIEAGO:0005886plasma membrane
BPTASGO:0000165MAPK cascade
BPNASGO:0007020microtubule nucleation
BPTASGO:0007411axon guidance
BPTASGO:0065003protein-containing complex assembly
BPIMPGO:0070373negative regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: RANBP9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RANBP9


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-8851805MET activates RAS signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
pidar_pathwayCoregulation of Androgen receptor activity
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_BDNFBDNF

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA2
iGMDRD420Leucascandrolide A3
iGMDRD579PF7502
iGMDRD151CHM-16
iGMDRD126Tipifarnib4
iGMDRD435BI-25366
iGMDRD123Isoevodiamine4
iGMDRD297Austocystin D2
iGMDRD193Fqi13
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD351GW843682X5
iGMDRD201SKI II2
iGMDRD85Ursolic acid3
iGMDRD446LY 21832403
iGMDRD213SMR0000686502
iGMDRD52Rotenone2
iGMDRD434BMS-5369242
iGMDRD705Nakiterpiosin6
iGMDRD121GMX17783
iGMDRD270Ciclosporin3
iGMDRD513BML-2593
iGMDRD322FK 8663
iGMDRD82Quiflapon2
iGMDRD60Quinoclamine3
iGMDRD505Pevonedistat3
iGMDRD562Navitoclax4
iGMDRD888Compound 441
iGMDRD506Fedratinib5
iGMDRD188Piperlongumine2
iGMDRD100Zebularine5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RANBP9

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